5 Surprising Things That Spike Blood Sugar (Besides Food!) | NHS Doctor Explains (2026)

Exercise, stress, sleep, infections, and hormones can all impact blood sugar levels, according to NHS doctor and general physician Dr. Amir Khan. These factors can cause temporary spikes in blood glucose, which may not always be a cause for concern. Dr. Khan emphasizes the importance of context and encourages readers to consult their doctors for personalized advice.

One surprising factor is stress, which triggers the release of cortisol, the fight-or-flight hormone. This hormone signals the liver to release stored glucose into the bloodstream, providing a quick energy boost. While this can be helpful in emergency situations, chronic stress can lead to persistent glucose spikes, which are detrimental to long-term health.

Poor sleep is another significant contributor to blood sugar issues. Even a single night of inadequate sleep can increase insulin resistance, causing glucose to remain in the bloodstream for longer. Chronic sleep deprivation is a major risk factor for type 2 diabetes, even for those with healthy diets.

Exercise, particularly intense or resistance training, can temporarily raise blood sugar levels as the body releases glucose for fuel. However, regular exercise ultimately improves insulin sensitivity, leading to better blood sugar regulation. This temporary spike is not necessarily harmful and can be a natural response to physical activity.

Infections and illnesses also play a role in blood sugar fluctuations. When the body fights off an infection, it releases more glucose into the bloodstream to fuel the immune system. This is why people with diabetes often experience higher blood sugar levels during illness, requiring medication adjustments.

Hormones, especially during the menstrual cycle, can significantly impact blood sugar levels. Higher progesterone levels during the luteal phase can make cells more insulin resistant, leading to elevated blood sugars. Declining estrogen levels during perimenopause and menopause further reduce insulin sensitivity, affecting glucose regulation. Women in their 40s and 50s may notice symptoms like weight gain, fatigue, and brain fog, which can be linked to these hormonal changes and blood sugar shifts.

Dr. Khan concludes that while not all blood sugar spikes are harmful, context is crucial. He advises readers to consult their doctors for personalized advice and to remember that blood sugar management is not solely dependent on diet. This article serves as a reminder that various factors, including lifestyle and hormonal changes, can influence blood glucose levels, and professional guidance is essential for maintaining optimal health.

5 Surprising Things That Spike Blood Sugar (Besides Food!) | NHS Doctor Explains (2026)
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